Immune cells known as monocytes are recruited to sites of inflammation, such as sites where microbes have invaded the body. Recruitment is mediated by soluble factors known as chemokines, but the precise identity of the chemokines that mediate the movement of monocytes from the bone marrow to the blood and then from the blood to the site of inflammation have not been well defined.
In a study that appears online in advance of publication in the April print issue of the Journal of Clinical Investigation, Israel Charo and colleagues from the Gladstone Institute of Cardiovascular Disease in San Francisco show that the chemokines MCP1 and MCP3 are crucial for monocyte movement from the bone marrow to the blood. Compared with normal mice, mice lacking either MCP1 or MCP3 had reduced numbers of monocytes in their blood and increased numbers of monocytes in their bone marrow. Similar observations were made in mice lacking the protein CCR2, which is the receptor to which MCP1 and MCP3 bind. The interaction of MCP1 and MCP3 with CCR2 was also shown to be required for the early recruitment of monocytes from the blood to sites of inflammation. This study indicates that MCP1/MCP3 and CCR2 are essential for the maintenance of a normal number of monocytes in the blood and for the early recruitment of monocytes from the blood to sites of inflammation.
TITLE: Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
AUTHOR CONTACT:
Israel F. Charo
Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
JCI table of contents: March 15, 2007
Contact: Karen Honey
Journal of Clinical Investigation
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